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Prognostic Inflammation Score in Surgical Patients with Colorectal Cancer
Journal of Korean Medical Science ; : 1793-1799, 2015.
Article Dans Anglais | WPRIM | ID: wpr-164156
ABSTRACT
Several inflammatory markers have been investigated as prognostic parameters in a variety of cancer population with mostly favorable results. This study aimed to verify the significance of common inflammatory markers as prognostic variables and assess whether a selective combination of them as prognostic inflammation score (PIS) could further improve their prognostic values in surgical patients with colorectal cancer (CRC). A total of 265 patients who had undergone curative resection of CRC were reviewed retrospectively. Preoperative levels of inflammatory markers such as serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), and neutrophil/lymphocyte ratio (NLR) were assessed by uni- and multivariate survival analysis with disease-free (DFS) and disease-specific survival (DSS). PIS was constructed with a selective combination of inflammatory markers which were independently significant. On univariate analysis, CRP, ESR, and NLR were significantly associated with DFS and DSS. On multivariate analysis, CRP and NLR were independently significant prognostic variables for DSS and DFS respectively (P=0.013, P=0.021). When PIS was constructed with combination of CRP and NLR, it was independently and significantly associated with both DFS and DSS (P=0.006, P=0.010). Furthermore, PIS was superior to CRP for DSS (HR=15.679 vs. HR=5.183), and NLR for DFS in terms of prognosticating power (HR=4.894 vs. HR=2.687). When PIS is constructed with combination of CRP and NLR, it is a potentially significant prognostic variable associated with poor survival regardless pathologic prognostic variables in patients with CRC after curative resection.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Sédimentation du sang / Protéine C-réactive / Tumeurs colorectales / Études rétrospectives / Numération des lymphocytes / Médiateurs de l'inflammation / Inflammation / Numération des leucocytes / Granulocytes neutrophiles Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Sédimentation du sang / Protéine C-réactive / Tumeurs colorectales / Études rétrospectives / Numération des lymphocytes / Médiateurs de l'inflammation / Inflammation / Numération des leucocytes / Granulocytes neutrophiles Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2015 Type: Article