A Case of 46 , XX Male / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 628-631, 1999.
Article
Dans Coréen
| WPRIM
| ID: wpr-16440
ABSTRACT
46, XX male is a rare sex cluomasomal constitution characterized by the development of bilateral testis in persons who lack a Y chomosome. The majority of affected persons have normal external genitalia and usually seek medical advice due to infertility, hypogonadism and/or gynecomastia in adulthood. Although Y chromosomsl sequences can be detected in the majority of male subjects with 46, XX karyotype, several studies have shown thst approximately 10 % of patients lack Y chromosomal material including the SRY ( sex-determining region of Y-chromosome) gene. Several hypothesis have been proposed to explain the etiology of this constitution. 1. Translocation of the testis-determining factor (TDF) fiom the Y to the X chromosome or autosome. 2. Acquisition of Y chromosome function by a mutant autosomal or X-linked gene. 3. Undetected mosaicism with Y-bearing cell line 4. Loss of Y chmmosome hom the XXY Klinefelter zygote. We experienced a case of 46, XX male who was 30 years old. We report a case with review of the literature.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Testicule
/
Chromosome X
/
Chromosome Y
/
Zygote
/
Lignée cellulaire
/
Statuts
/
Protéine de la région déterminant le sexe du chromosome Y
/
Gènes liés au chromosome X
/
Caryotype
/
Système génital
Limites du sujet:
Adulte
/
Humains
/
Mâle
langue:
Coréen
Texte intégral:
Korean Journal of Obstetrics and Gynecology
Année:
1999
Type:
Article
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