Early Start of Dialysis Has No Survival Benefit in End-Stage Renal Disease Patients
Journal of Korean Medical Science
;
: 1177-1181, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-164997
ABSTRACT
The timing for dialysis initiationis still debated. The aim of this study was to compare mortality rates, using a propensity-score approach, in dialysis patients with early or late starts. From January 2000 to June 2009, incident adult patients (n = 836) starting dialysis for end-stage renal disease (ESRD) were enrolled. The patients were assigned to either an early- or late-start group depending on the initiation time of the dialysis. After propensity-score-basedmatching, 450 patients remained. At the initiation of dialysis, the mean estimated glomerular filtration rate (eGFR) was 11.1 mL/min/1.73 m2 in the early-start group compared with 6.1 mL/min/1.73 m2 in the late-start group. There were no significant differences in survival between the patients in the early- and late-start groups (Log rank tests P = 0.172). A higher overall mortality risk was observed in the early-start group than in the late-start group for the patients aged > or = 70 yr (hazard ratio [HR] 3.29; P = 0.048) and/or who had albumin levels > or = 3.5 g/dL (HR 2.53; P = 0.046). The survival of the ESRD patients was comparable between the patients in the early and late-start groups. The time to initiate dialysis should be determined based on clinical findings as well as the eGFR.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Facteurs temps
/
Sérumalbumine
/
Modèles des risques proportionnels
/
Facteurs de risque
/
Facteurs âges
/
Dialyse rénale
/
Estimation de Kaplan-Meier
/
Score de propension
/
Débit de filtration glomérulaire
/
Défaillance rénale chronique
Type d'étude:
Etude d'étiologie
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Journal of Korean Medical Science
Année:
2012
Type:
Article
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