Fatal Infectious Mononucleosis: A case report / 대한법의학회지
Korean Journal of Legal Medicine
;
: 188-191, 2007.
Article
Dans Coréen
| WPRIM
| ID: wpr-165976
ABSTRACT
Infectious mononucleosis(IM) is a benign self-limiting disease and result from a polyclonal B cell proliferation secondary to Epstein-Barr virus (EBV) infections. The infection is controlled by cytotoxic T cells triggered by EBV infected B cells. However, rare cases develop severe or fatal IM accompanied by hemophagocytic syndrome. We report a case of a 4-year-old girl who presented with high fever, hepatosplenomegaly, hepatic failure, pancytopenia and coagulopathy. Despite intensive treatment, the patient's condition deteriorated rapidly and died 3 days after admission. At autopsy, there was prominent infiltration of atypical lymphocytes with hemophagocytosis in multiple organs, especially liver, spleen and lymph nodes. Atypical lymphocytes were immunopositive for T cell markers and showed positive signal in EBV in situ hybridization.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pancytopénie
/
Autopsie
/
Rate
/
Lymphocytes B
/
Lymphocytes
/
Lymphocytes T
/
Défaillance hépatique
/
Hybridation in situ
/
Herpèsvirus humain de type 4
/
Prolifération cellulaire
Limites du sujet:
Enfant d'âge préscolaire
/
Femelle
/
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Legal Medicine
Année:
2007
Type:
Article
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