Your browser doesn't support javascript.
loading
Elevated Calcium after Acute Ischemic Stroke: Association with a Poor Short-Term Outcome and Long-Term Mortality / 대한뇌졸중학회지
Journal of Stroke ; : 54-59, 2015.
Article Dans Anglais | WPRIM | ID: wpr-166387
ABSTRACT
BACKGROUND AND

PURPOSE:

An elevated intracellular calcium level is known to be a major initiator and activator of ischemic cell death pathway; however, in recent studies, elevated serum calcium levels have been associated with better clinical outcomes and smaller cerebral infarct volumes. The pathophysiological role played by calcium in ischemic stroke is largely unknown.

METHODS:

Acute stroke patients from a prospective stroke registry, consecutively admitted during October 2002-September 2008, were included. Significant associations between the modified Rankin scale distribution at discharge and serum calcium or albumin-corrected calcium were identified using ordinal logistic regression analysis. Cox proportional hazard models were used for survival analysis.

RESULTS:

Mean serum calcium and albumin-corrected calcium levels of the 1,915 participants on admission were 8.97+/-0.58 mg/dL and 9.07+/-0.49 mg/dL, respectively. Second [adjusted odds ratio 1.32 (95% confidence interval 1.07-1.61)] and third [1.24 (1.01-1.53)] tertiles of serum calcium level and the third [1.24 (1.01-1.53)] tertile of albumin-corrected calcium level were found to be independent risk factors for a poor discharge outcome. Significant relationships were observed with serum calcium [1.19 (1.03-1.38)] and albumin-corrected calcium [1.21(1.01-1.44)] as linear variables. However, only albumin-corrected calcium was associated with long-term mortality, third tertile [adjusted hazard ratio 1.40 (1.07-1.83)], and increase by 1 mg/dL [1.46 (1.16-1.84)].

CONCLUSIONS:

Elevated albumin-corrected serum calcium levels are associated with a poorer short-term outcome and greater risk of long-term mortality after acute ischemic stroke.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Modèles logistiques / Odds ratio / Modèles des risques proportionnels / Infarctus cérébral / Calcium / Études prospectives / Facteurs de risque / Mortalité / Mort cellulaire / Accident vasculaire cérébral Type d'étude: Etude d'étiologie / Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Journal of Stroke Année: 2015 Type: Article

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Modèles logistiques / Odds ratio / Modèles des risques proportionnels / Infarctus cérébral / Calcium / Études prospectives / Facteurs de risque / Mortalité / Mort cellulaire / Accident vasculaire cérébral Type d'étude: Etude d'étiologie / Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Journal of Stroke Année: 2015 Type: Article