Effect of ApoE Genotype on the Relationship between Nutritional Risk and Cognition in the Elderly
Journal of the Korean Geriatrics Society
;
: 177-185, 2006.
Article
Dans Coréen
| WPRIM
| ID: wpr-167575
ABSTRACT
BACKGROUND:
The purpose of this study is to find out the effect of ApoE genotype on the relationship between nutritional risk and cognition of the elderly in a community.METHODS:
A total of 996 subjects (343 men and 653 women) aged 60~91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, K-SGDS (Korean version of Short Form Geriatric Depression Scale), K-MMSE (Korean version-Mini Mental State Examina- tion), and NSI (Nutritional Screening Initiative) checklist. We also examined blood pressure, fasting serum glucose, lipid profile, body mass index, and ApoE genotyping.RESULTS:
649 subjects (65.2%) were on good nutritional state (NSI score or = 3). On multiple logistic regression analysis, moderate or high nutritional risk was associated with an increa- sed risk for cognitive impairment (K-MMSE score < or = 17) after adjustment with age, sex, K-GDS and educational level in the absence of ApoE epsilon4 allele (OR 1.78, 95% CI 1.15-2.77).CONCLUSION:
These results suggest that nutritional risk may be associated with cognitive function in the elderly only in the absence of ApoE epsilon4 allele.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Apolipoprotéines E
/
Glycémie
/
Pression sanguine
/
Indice de masse corporelle
/
Modèles logistiques
/
Dépistage de masse
/
Enquêtes et questionnaires
/
Jeûne
/
Cognition
/
Démence
Type d'étude:
Etude d'étiologie
/
Étude pronostique
/
Facteurs de risque
/
Étude de dépistage
Limites du sujet:
Adulte très âgé
/
Humains
/
Mâle
langue:
Coréen
Texte intégral:
Journal of the Korean Geriatrics Society
Année:
2006
Type:
Article
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