Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures / 소아과
Korean Journal of Pediatrics
;
: 50-54, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-168713
ABSTRACT
PURPOSE:
The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM.METHODS:
A retrospective analysis of 18 neonatal patients with seizures, who were treated with LEV, including 151 serum samples, was performed. The mean loading dose was 20 mg/kg, followed by a mean maintenance dose of 29 mg/kg/day.RESULTS:
Seventeen neonates (94%) had seizure cessation within 1 week and 16 (84%) remained seizure-free at 30 days under the LEV therapy. The mean serum concentration of LEV was 8.7 µg/mL. Eight samples (5%) were found above the therapeutic range. No serious adverse effects were detected. In the PPK analysis for Korean neonates, the half-life was 9.6 hours; clearance, 0.357 L/hr; and volume of distribution, 4.947 L, showing differences from those in adults.CONCLUSION:
LEV is a safe and effective option for the treatment of neonatal seizures with careful therapeutic drug monitoring.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Crises épileptiques
/
Pharmacocinétique
/
Études rétrospectives
/
Surveillance des médicaments
/
Période
Type d'étude:
Étude observationnelle
Limites du sujet:
Adulte
/
Humains
/
Nouveau-né
langue:
Anglais
Texte intégral:
Korean Journal of Pediatrics
Année:
2017
Type:
Article
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