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Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures / 소아과
Korean Journal of Pediatrics ; : 50-54, 2017.
Article Dans Anglais | WPRIM | ID: wpr-168713
ABSTRACT

PURPOSE:

The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM.

METHODS:

A retrospective analysis of 18 neonatal patients with seizures, who were treated with LEV, including 151 serum samples, was performed. The mean loading dose was 20 mg/kg, followed by a mean maintenance dose of 29 mg/kg/day.

RESULTS:

Seventeen neonates (94%) had seizure cessation within 1 week and 16 (84%) remained seizure-free at 30 days under the LEV therapy. The mean serum concentration of LEV was 8.7 µg/mL. Eight samples (5%) were found above the therapeutic range. No serious adverse effects were detected. In the PPK analysis for Korean neonates, the half-life was 9.6 hours; clearance, 0.357 L/hr; and volume of distribution, 4.947 L, showing differences from those in adults.

CONCLUSION:

LEV is a safe and effective option for the treatment of neonatal seizures with careful therapeutic drug monitoring.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Crises épileptiques / Pharmacocinétique / Études rétrospectives / Surveillance des médicaments / Période Type d'étude: Étude observationnelle Limites du sujet: Adulte / Humains / Nouveau-né langue: Anglais Texte intégral: Korean Journal of Pediatrics Année: 2017 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Crises épileptiques / Pharmacocinétique / Études rétrospectives / Surveillance des médicaments / Période Type d'étude: Étude observationnelle Limites du sujet: Adulte / Humains / Nouveau-né langue: Anglais Texte intégral: Korean Journal of Pediatrics Année: 2017 Type: Article