A Case of Prothionamide Induced Hepatitis on Patient with Multi-Drug Resistant Pulmonary Tuberculosis / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 251-256, 2011.
Article
Dans Ko
| WPRIM
| ID: wpr-169148
Responsable en Bibliothèque :
WPRO
ABSTRACT
The prevalence of multi-drug resistant tuberculosis (MDR-TB), which is resistant to isoniazid and rifampin, has been increasing in Korea. And the side effects of 2nd line anti-tuberculosis medications, including drug-induced hepatitis, are well known. Although prothionamide (PTH) is one of the most useful anti-TB medications and although TB medication-induced acute hepatitis is a severe complication, there are only a few published case reports about prothionamide induced hepatitis. In this case report, a 22 year old male was diagnosed with pulmonary MDR-TB and was administered 2nd line anti-TB mediations, including PTH. Afterwards, he had a spiking fever and his liver enzymes were more than 5 times greater than the upper limit of the normal range. He was then diagnosed with drug-induced hepatitis by liver biopsy. His symptoms and liver enzyme elevation were improved after stopping PTH. Accordingly, we report this case of an association between PTH and acute hepatitis.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Protionamide
/
Valeurs de référence
/
Rifampicine
/
Tuberculose pulmonaire
/
Biopsie
/
Prévalence
/
Tuberculose multirésistante
/
Lésions hépatiques dues aux substances
/
Fièvre
/
Hépatite
Type d'étude:
Prevalence_studies
Limites du sujet:
Humans
/
Male
Pays comme sujet:
Asia
langue:
Ko
Texte intégral:
Tuberculosis and Respiratory Diseases
Année:
2011
Type:
Article