Effects of Curcumin and Genistein on Phorbol Ester or Tumor Necrosis Factor-alpha-Induced Mucin Production from Human Airway Epithelial Cells / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 218-223, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-169153
ABSTRACT
BACKGROUND:
We investigated whether curcumin and genistein affect the MUC5AC mucin production from human airway epithelial cells that is induced by phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-alpha (TNF-alpha).METHODS:
Confluent NCI-H292 cells were pretreated with each agent for 30 min and then stimulated with PMA or TNF-alpha for 24 hours. MUC5AC mucin production was measured by an ELISA.RESULTS:
(1) Curcumin dose-dependently inhibited the production of MUC5AC mucin that was induced by PMA or TNF-alpha; (2) Genistein inhibited PMA-induced MUC5AC mucin production. However, it did not decrease TNF-alpha-induced MUC5AC mucin production.CONCLUSION:
These results suggest that curcumin and genistein inhibit the production of airway mucin induced by PMA.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phorbols
/
Facteur de nécrose tumorale alpha
/
Génistéine
/
Curcumine
/
Cellules épithéliales
/
Mucine-5AC
/
Mucines
/
Nécrose
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Tuberculosis and Respiratory Diseases
Année:
2011
Type:
Article
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