Down-Regulation of Serum High-Mobility Group Box 1 Protein in Patients with Pulmonary Tuberculosis and Nontuberculous Mycobacterial Lung Disease / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 153-158, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-169290
ABSTRACT
BACKGROUND:
Recently, increased levels of high-mobility group box 1 protein (HMGB1) have been identified in various inflammatory conditions and infections. However, no studies have evaluated the HMGB1 level in nontuberculous mycobacterial (NTM) lung disease, and compared it to mycobacterial lung disease.METHODS:
A total of 60 patients newly diagnosed with NTM lung disease, 44 culture-positive pulmonary tuberculosis (TB) patients, and 34 healthy controls, were included in this study. The serum HMGB1 concentrations were quantified using HMGB1 enzyme-linked immunosorbent assay kits.RESULTS:
Serum HMGB1 level in patients with pulmonary TB or NTM lung disease, was significantly lower than that of the healthy controls. In addition, the serum HMGB1 level in TB patients was significantly lower than patients with NTM lung disease. However, the levels in NTM patient subgroups did not differ according to the causative species, disease progression, and disease phenotype.CONCLUSION:
Although low levels of serum HMGB1 has the potential to be a marker of mycobacterial lung disease, these levels were unable to differentiate disease progression and disease phenotype in NTM lung diseases.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phénotype
/
Tuberculose
/
Tuberculose pulmonaire
/
Test ELISA
/
Régulation négative
/
Évolution de la maladie
/
Protéine HMGB1
/
Poumon
/
Maladies pulmonaires
/
Mycobactéries non tuberculeuses
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Tuberculosis and Respiratory Diseases
Année:
2017
Type:
Article
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