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Diseases having an influence on inhibition of angiogenesis as risk factors of osteonecrosis of the jaw
Journal of the Korean Association of Oral and Maxillofacial Surgeons ; : 271-277, 2016.
Article Dans Anglais | WPRIM | ID: wpr-169370
ABSTRACT

OBJECTIVES:

The objective of this study was to retrospectively investigate the association of diseases having an influence on inhibition of angiogenesis such as hypertension, diabetes mellitus type II, hypercholesterolemia, and rheumatoid arthritis (RA) with the development of osteonecrosis of the jaws. MATERIALS AND

METHODS:

The 135 patients were allocated into 4 groups of bisphosphonate-related osteonecrosis of the jaw (BRONJ) group (1A); non-BRONJ group (1B); osteonecrosis of the jaw (ONJ) group (2A); and control group (2B), according to histologic results and use of bisphosphonate. This retrospective study was conducted with patients who were treated in one institute from 2012 to 2013. Fisher's exact test and logistic regression analysis were used to analyze the odds ratios of diseases having an influence on inhibition of angiogenesis for development of ONJ.

RESULTS:

The effects of diabetes and hypertension were not statistically significant on development of ONJ. When not considering bisphosphonate use, RA exhibited a high odds ratio of 3.23 (P=0.094), while hyperlipidemia showed an odds ratio of 2.10 (P=0.144) for development of ONJ. More than one disease that had an influence on inhibition of angiogenesis showed a statistically significant odds ratio of 2.54 (P=0.012) for development of ONJ.

CONCLUSION:

Patients without diseases having an influence on inhibition of angiogenesis were at less risk for developing ONJ.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Ostéonécrose / Polyarthrite rhumatoïde / Modèles logistiques / Odds ratio / Études rétrospectives / Facteurs de risque / Inhibiteurs de l'angiogenèse / Diabète / Ostéonécrose de la mâchoire associée aux biphosphonates / Hypercholestérolémie Type d'étude: Etude d'étiologie / Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Journal of the Korean Association of Oral and Maxillofacial Surgeons Année: 2016 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Ostéonécrose / Polyarthrite rhumatoïde / Modèles logistiques / Odds ratio / Études rétrospectives / Facteurs de risque / Inhibiteurs de l'angiogenèse / Diabète / Ostéonécrose de la mâchoire associée aux biphosphonates / Hypercholestérolémie Type d'étude: Etude d'étiologie / Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Journal of the Korean Association of Oral and Maxillofacial Surgeons Année: 2016 Type: Article