Relationship between Catch-up Growth and Changes in Insulin, Leptin, IGF-I, Adiponectin, and Ghrelin in Infants Born Full-term Small for Gestational Age / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology
;
: 112-118, 2011.
Article
Dans Coréen
| WPRIM
| ID: wpr-169409
ABSTRACT
PURPOSE:
The aim of the study was to investigate postnatal changes in growth and insulin, leptin, IGF-I, adiponectin, and ghrelin, and to examine the relationship of these hormones with catch-up growth in full-term small for gestational age (SGA) infants.METHODS:
SGA was defined as a birth weight less than the ten percentile. Weight and height were measured at birth, 1 month, 6 months, 1 year, and 2 years of age in 70 SGA infants (40 females and 30 males). The infants were subdivided according to their weight and height catch-up growth (CUG) at 2 years old. CUG is defined as reaching a standard deviation score (SDS) of > -2 SDS. Blood samples were serially taken for insulin, leptin, insulinlike growth factor (IGF)-I, adiponectin, and ghrelin.RESULTS:
1) Dramatic CUG for weight and height occurred during the first year of life; weight and height growth gain decreased thereafter. 2) Non-catch-up growth (NCUG) infants showed more decreased weight and height growth gain than CUG infants between the first and second year of life. 3) Weight CUG was 77.1% and height CUG was 75.8% in the SGA infants. 4) Weight CUG infants showed significantly higher leptin and ghrelin levels than in weight NCUG infants at the age of 1 year (P <0.05). 5) Height CUG infants showed significantly higher leptin and ghrelin levels than in height NCUG infants at the age of 1 year (P <0.05).CONCLUSION:
CUG for weight and height occurred during the first year of life and growth velocity decreased thereafter. Significant corresponding changes occurred with regard to serum leptin and ghrelin.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Poids de naissance
/
Nourrisson petit pour son âge gestationnel
/
Facteur de croissance IGF-I
/
Âge gestationnel
/
Leptine
/
Parturition
/
Adiponectine
/
Ghréline
/
Insuline
Limites du sujet:
Femelle
/
Humains
/
Bébé
/
Nouveau-né
langue:
Coréen
Texte intégral:
Journal of Korean Society of Pediatric Endocrinology
Année:
2011
Type:
Article
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