Alzheimer's Disease: Clinical Trials and Future Perspectives / 대한정신약물학회지
Korean Journal of Psychopharmacology
; : 131-135, 2012.
Article
de Ko
| WPRIM
| ID: wpr-169424
Bibliothèque responsable:
WPRO
ABSTRACT
Alzheimer's disease is increasingly common in elderly population with a large socioeconomic burden. Current available drugs for Alzheimer's disease are acetylcholinesterase inhibitors and N-methyl-D-aspartate receptor antagonist. Much effort is directed towards not just symptomatic treatments but disease-modifying treatments. Several drugs with differing targets and mechanisms of action are under development for the treatment of Alzheimer's disease. Phase III trials of dimebon, Ginkgo biloba, non-steroidal anti-inflammatory drugs, phenserine, statins, semagacestat, tarenflurbil, tramiprosate, valproate, xaliproden have been completed without demonstrating adequate efficacy. Encouraging results would be expected from ongoing phase III trials of bapineuzumab and solanezumab. The clinical trials for the disease-modifying treatment of Alzheimer's disease have resulted in both promise and disappointment.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Physostigmine
/
Pyridines
/
Azépines
/
Taurine
/
Flurbiprofène
/
Anticholinestérasiques
/
N-Méthyl-aspartate
/
Acide valproïque
/
Ginkgo biloba
/
Alanine
Limites du sujet:
Aged
/
Humans
langue:
Ko
Texte intégral:
Korean Journal of Psychopharmacology
Année:
2012
Type:
Article