Immune Thrombocytopenic Purpura in a Patient with Preexisting Ulcerative Colitis: A Case Report / 대한소화기내시경학회지
Korean Journal of Gastrointestinal Endoscopy
;
: 44-48, 2002.
Article
Dans Coréen
| WPRIM
| ID: wpr-170266
ABSTRACT
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with evidence of immune activation and is associated with extraintestinal diseases in numerous target tissues. Extraintestinal manifestations of UC are well described in numerous tissues, most notably mucotaneous, synovial, biliary, and opthalmic. Among hematological complications of UC, autoimmune hemolytic anemia is often reported, but immune-mediated thrombocytopenia (ITP) is rare. We present one case in which exacerbation of UC sequentially induced development of ITP. Platelet-associated antibodies were positive. Bone marrow examinations revealed increased megakaryocyte number. ITP was treated with corticosteroids, intravenous immune gamma- globulin and plasmapheresis. However, because previous treatments were not successful, splenectomy was done. This may provide further evidence that ITP is causally associated with UC, and is the result of immunostimulation from luminal antigens and altered immunoregulation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phénobarbital
/
Splénectomie
/
Thrombopénie
/
Ulcère
/
Myélogramme
/
Mégacaryocytes
/
Maladies inflammatoires intestinales
/
Rectocolite hémorragique
/
Immunisation
/
Plasmaphérèse
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Gastrointestinal Endoscopy
Année:
2002
Type:
Article
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