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Double Autologous Stem Cell Transplantation for Multiple Myeloma: A Korean Single Center Study
The Korean Journal of Internal Medicine ; : 237-242, 2005.
Article Dans Anglais | WPRIM | ID: wpr-170410
ABSTRACT

BACKGROUND:

Although high dose chemotherapy coupled with an autologous stem cell transplantation (ASCT) is widely accepted as effective therapy for multiple myeloma (MM), few reports are available in Korea, especially in the area of double ASCT. We present the results of an institutional retrospective study of 12 patients with MM treated by double ASCT.

METHODS:

Eligible patients received induction therapy using vincristine, adriamycin, dexamethasone (VAD), and mobilization was performed using cyclophosphamide plus lenograstim. High-dose melphalan (total 200 mg/m2) was used to condition the ASCT.

RESULTS:

The median interval from diagnosis to ASCT was 6 months (range, 1.8-15.3 months). The median interval between the 1st and 2nd ASCT was 4.4 months (range 2.1-48.7 months). The median follow up was 18.3 months (range 8.1-50.5 months) for the nine surviving patients. No therapy-related mortality occurred. Following induction chemotherapy, two patients experienced CR. Following double ASCT, eight patients experienced CR. The 5 year OS was 59%. The median duration of event free survival was 2.13 years (95% CI, 0.84-3.42).

CONCLUSION:

Although the results of study did not demonstrate the advantage of double ASCT, this is the first report to outline the outcome of double ASCT for Korean MM patients.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Transplantation autologue / Vincristine / Protéines recombinantes / Dexaméthasone / Protocoles de polychimiothérapie antinéoplasique / Doxorubicine / Études rétrospectives / Facteur de stimulation des colonies de granulocytes / Transplantation de cellules souches / Corée Type d'étude: Étude observationnelle Limites du sujet: Adulte / Adulte très âgé / Femelle / Humains / Mâle Pays comme sujet: Asie langue: Anglais Texte intégral: The Korean Journal of Internal Medicine Année: 2005 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Transplantation autologue / Vincristine / Protéines recombinantes / Dexaméthasone / Protocoles de polychimiothérapie antinéoplasique / Doxorubicine / Études rétrospectives / Facteur de stimulation des colonies de granulocytes / Transplantation de cellules souches / Corée Type d'étude: Étude observationnelle Limites du sujet: Adulte / Adulte très âgé / Femelle / Humains / Mâle Pays comme sujet: Asie langue: Anglais Texte intégral: The Korean Journal of Internal Medicine Année: 2005 Type: Article