Efficacy of Biodegradable Microneedle Patches on Periorbital Wrinkles / 대한피부과학회지
Korean Journal of Dermatology
; : 597-607, 2014.
Article
de Ko
| WPRIM
| ID: wpr-170797
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND: Biodegradable microneedle technology is a recently developed method to deliver medical and pharmaceutical medications into the skin, and is expected to yield better treatment results than topical application methods. OBJECTIVE: To evaluate the efficacy of hyaluronic acid (HA)-based microneedle patches and epidermal growth factor (EGF)-containing microneedle patches on periorbital wrinkle improvement. METHODS: A 20-week randomized, double-blind study was performed. Twenty-five Korean patients with periorbital wrinkles and a wrinkle severity rating scale (WSRS) score above 2 were enrolled into the study. The patients completed the study using the two different types of patches on each side of the designated periorbital wrinkles area every other day for 8 weeks. Patients were requested for an additional 12-week follow up. Wrinkle improvements were assessed by WSRS score, subjective patient satisfaction score, and imaging analysis using the visiometer, corneometer, cutometer, and mexameter, respectively (Courage&Khazaka, Cologne, Germany). RESULTS: Both the HA-based microneedle patch and EGF-containing HA-based microneedle patch had positive effects on WSRS score, patient satisfaction levels, and corneometer result with statistically significant differences. No significant side effects were noticed. CONCLUSION: With respect to efficacy, no statistical difference between the two groups were noted, indicating that the anti-wrinkle effects of the microneedle patch may solely be due to the HA rather than the EGF.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Peau
/
Méthode en double aveugle
/
Études de suivi
/
Satisfaction des patients
/
Facteur de croissance épidermique
/
Acide hyaluronique
Type d'étude:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Korean Journal of Dermatology
Année:
2014
Type:
Article