A Case of a False-Positive Anti-Myeloperoxidase Antibody ELISA in a Patient with Hypothyroidism / 전남의대학술지
Chonnam Medical Journal
; : 48-50, 2011.
Article
de En
| WPRIM
| ID: wpr-170941
Bibliothèque responsable:
WPRO
ABSTRACT
We present a case of a false-positive anti-myeloperoxidase (MPO) antibody result on an ELISA in a patient with anti-thyroid microsomal antibody (TMA)-positive hypothyroidism. A 41-year-old woman presented with dyspnea on exertion. The initial evaluation revealed pericardial effusion associated with hypothyroidism. In addition, microscopic hematuria with normal renal function and positive cytoplasmic anti-neutrophil cytoplasmic antibodies (c-ANCA) on immunofluorescent assay were found. In further evaluation, elevated anti-TMA and MPO antibodies by ELISA. While no definite signs of vasculitis were present, the clinical state improved with thyroid hormone replacement and diuretics. Anti-MPO antibody was still positive in the follow-up tests, and microscopic hematuria persisted. On the basis of previous reports that thyroid peroxidase and MPO molecules contain cross-reactive epitopes that are exposed in denaturated molecules, we suggest that in a patient with anti-TMA-positive hypothyroidism, anti-MPO antibody might also be positive on ELISA without clinical signs of vasculitis.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Épanchement péricardique
/
Glande thyroide
/
Vascularite
/
Test ELISA
/
Études de suivi
/
Anticorps anti-cytoplasme des polynucléaires neutrophiles
/
Cytoplasme
/
Diurétiques
/
Dyspnée
/
Hématurie
Type d'étude:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites du sujet:
Adult
/
Female
/
Humans
langue:
En
Texte intégral:
Chonnam Medical Journal
Année:
2011
Type:
Article