Soluble glucocorticoid-induced TNF receptor (sGITR) induces inflammation in mice
Experimental & Molecular Medicine
;
: 358-364, 2003.
Article
Dans Anglais
| WPRIM
| ID: wpr-171366
ABSTRACT
Glucocorticoid-induced TNF receptor (GITR) was a new member of the TNF/nerve growth factor receptor (TNFR/ NGFR) family and induced in murine T cells by dexamathasone. Recombinant soluble GITR (sGITR) induced an inflammation in peritoneal membrane and changes in spleen after i.p. injection of 3 mg/kg in C57BL/6 mice. Spleen was enlarged and percentage of neutrophils and monocytes were increased. The area of red pulp in spleen was increased, while that of white pulp was decreased after GITR injection. The thickening of membrane and neutrophil infiltration was observed in peritoneal membrane with increased myeloperoxidase activity. At later time, neutrophil infiltration moved to inside the tissue with tissue damage. GITR ligand and GITR were expressed constitutively on the surface of spleen cells and cells from peritoneal fluid. In contrast, no significant change in the spleen and in peritoneal membrane was observed in mice treated with LPS. GITR may play a role in body's inflammatory processes.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Solubilité
/
Rate
/
Protéines de transport
/
Récepteurs facteur croissance nerf
/
Récepteurs aux facteurs de nécrose tumorale
/
Cytométrie en flux
/
Inflammation
/
Injections
/
Souris de lignée C57BL
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Experimental & Molecular Medicine
Année:
2003
Type:
Article
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