Local Reactions after Intraarticular Hyaluronic Acid Injection for Osteoarthritis of the Knee / 대한류마티스학회지

ABSTRACT

OBJECTIVE: To describe the frequency and the nature of acute local reactions following intraarticular hyaluronate injection. METHODS: Retrospective review of patients with osteoarthirtis of the knee treated with intraarticular hyaluronate injection between June, 2001 and March, 2002. The frequency, symptoms and signs, and duration and treatment of the local reactions were analyzed. RESULTS: Nineteen patients received 124 hyaluronates injections to knees. Seven (36.8%) patients developed local reactions in 9 (7.3%) knees. Transient pain occurred in 3 patients. However, persistent pain accompanied by swelling developed in 4 patients. Patients who developed transient pain did not required treatment with self-limiting course, but patients with joint swelling required arthrocentesis and intraarticular corticosteroid injection. CONCLUSION: Intraarticular hyaluronate injection was associated with significant local reactions. Local reactions were more frequent and severe than previously described with occasional development of joint swelling requiring arthrocentesis.