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Impact of Caveolin-1 Expression on the Prognosis of Transitional Cell Carcinoma of the Upper Urinary Tract
Journal of Korean Medical Science ; : 296-301, 2008.
Article Dans Anglais | WPRIM | ID: wpr-173550
ABSTRACT
This study aimed to investigate the relationship of caveolin-1 expression with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCCUUT). Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 98 patients, who had undergone radical nephroureterectomy, were stained immunohistochemically using antibodies against caveolin-1. The expression pattern of caveolin- 1 was compared with the clinicopathological variables. The caveolin-1 expression was significantly correlated with T stage (p<0.001) and grade (p=0.036). The survival rate of patients with caveolin-1 positive tumors was significantly lower than that of patients with caveolin-1 negative tumors (p<0.0001). The univariate analyses identified T stage, grade, and caveolin-1 expression as significant prognostic factors for cancer-specific survival, whereas the multivariate analyses indicated that T stage and caveolin-1 expression were independent prognostic factors. These results show that the increased expression of caveolin-1 is associated with tumor progression and poor prognosis in TCC-UUT, suggesting that caveolin-1 may play an important role in the progression of TCC-UUT.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Carcinome transitionnel / Régulation de l&apos;expression des gènes tumoraux / Tumeurs urologiques / Survie sans rechute / Évolution de la maladie / Analyse de profil d&apos;expression de gènes / Cavéoline-1 Type d'étude: Étude pronostique Limites du sujet: Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2008 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Carcinome transitionnel / Régulation de l&apos;expression des gènes tumoraux / Tumeurs urologiques / Survie sans rechute / Évolution de la maladie / Analyse de profil d&apos;expression de gènes / Cavéoline-1 Type d'étude: Étude pronostique Limites du sujet: Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2008 Type: Article