Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells
Experimental & Molecular Medicine
;
: 469-476, 2007.
Article
Dans Anglais
| WPRIM
| ID: wpr-174057
ABSTRACT
Osteosarcoma is the most common primary bone tumor, but the pathogenesis is not well understood. While cyclooxygeanse-2 (COX-2) is known to be closely associated with tumor growth and metastasis in several kinds of human tumors, the function of COX-2 in osteosarcoma is unclear. Therefore, to investigate the function of COX-2 in osteosarcoma, we established stable cell lines overexpressing COX-2 in U2OS human osteosarcoma cells. COX-2 overexpression as well as prostaglandin E(2) treatment promoted proliferation of U2OS cells. In addition, COX-2 overexpression enhanced mobility and invasiveness of U2OS cells, which was accompanied by increases of matrix metalloproteinase-2 and -9 (MMP-2 and -9) activities. Selective COX-2 inhibitors, NS-398 and celecoxib, inhibited cell proliferation and abrogated the enhanced mobility, invasiveness and MMP activities induced by COX-2 overexpression. These results suggest that COX-2 is directly associated with cell proliferation, migration and invasion in human osteosarcoma cells, and the therapeutic value of COX-2 inhibitors should be evaluated continuously.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pyrazoles
/
Sulfonamides
/
Tumeurs osseuses
/
Dinoprostone
/
Ostéosarcome
/
Mouvement cellulaire
/
Matrix metalloproteinase 2
/
Matrix metalloproteinase 9
/
Lignée cellulaire tumorale
/
Prolifération cellulaire
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Experimental & Molecular Medicine
Année:
2007
Type:
Article
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