Immunohistochemical Study of Bcl-2 Oncoprotein Expression in Childhood Non-Hodgkin's Lymphoma
Journal of the Korean Pediatric Society
;
: 1265-1274, 1997.
Article
Dans Coréen
| WPRIM
| ID: wpr-174200
ABSTRACT
PURPOSE:
The aim of the present study was to assess the clinicopatholgical significance of Bcl-2 oncoprotein expression in childhood non-Hodgkin's lymphoma (NHL).METHODS:
We have assessed 16 cases of childhood NHL during last 6 years from 1990 to 1995. Bcl-2 oncoprotein expression has been semiquantitatively analyzed in paraffin sections from 16 cases of childhood NHL with 39 control cases of adult NHL. The expression of Bcl-2 oncoprotein was correlated with histologic grade, immunophenotype, proliferative activity as measured by immunostain of Ki-67 antigen, clinical stage, and survival rate (event free survival rate, EFS).RESULTS:
1) Bcl-2 oncoprotein expression significantly decreased according to increase of histological grade (P0.05). 5) EFS of patients was significantly correlated with Bcl-2 oncoprotein expression, that is, reduced EFS was demonstrated in the patients with low Bcl-2 oncoprotein expression (P<0.05).CONCLUSIONS:
Thus Bcl-2 oncoprotein, as demonstrated immunohistochemically in routinely paraffin embedded tissue, can be restrictively used in prediction of prognosis and grade of childhood NHL, in aggrement with the role of Bcl-2 oncoprotein in blocking of apoptosis and indirect contribution to increase of cellular proliferative activity of NHL.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Paraffine
/
Pronostic
/
Lymphome malin non hodgkinien
/
Lymphocytes B
/
Lymphocytes T
/
Taux de survie
/
Apoptose
/
Antigène KI-67
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte
/
Enfant
/
Humains
langue:
Coréen
Texte intégral:
Journal of the Korean Pediatric Society
Année:
1997
Type:
Article
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