Association between the BDNF Val66Met Polymorphism and Chronicity of Depression
Psychiatry Investigation
;
: 56-61, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-17597
ABSTRACT
OBJECTIVE:
Both clinical and biological factors influence the course of depressive disorders. This study tested for associations between the brain-derived neurotrophic factor (BDNF) gene at the Val66Met locus and the course of major depressive disorder (MDD).METHODS:
Three hundred ten Korean subjects (209 patients, 101 controls) were genotyped for rs6265 at nucleotide 196 (G/A), which produces an amino acid substitution at codon 66 (Val66Met) of the gene for BDNF. Course of illness was evaluated both by chronicity of current episode (episode duration >24 months) and by the lifetime history of recurrences.RESULTS:
Patients with the Met/Met BDNF genotype had a significantly higher rate of chronic depression than all others. There was a significant dose effect of the Met allele on chronicity. Compared with the Val/Val genotype, the relative risk of chronicity was 1.67 for the Val/Met genotype, and 2.58 for the Met/Met genotype. Lifetime history of recurrent episodes was not related to BDNF genotypes but was significantly associated with younger age of onset and with a history of depression in first degree relatives.CONCLUSION:
BDNF genotyping may be informative for anticipating chronicity in major depression.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Codon
/
Facteurs biologiques
/
Âge de début
/
Facteur neurotrophique dérivé du cerveau
/
Substitution d'acide aminé
/
Dépression
/
Trouble dépressif majeur
/
Trouble dépressif
/
Allèles
/
Génotype
Type d'étude:
Etude d'étiologie
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Psychiatry Investigation
Année:
2013
Type:
Article
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