Cell Processing: Current Status and Future Directions
Yonsei Medical Journal
;
: S1-S4, 2004.
Article
Dans Anglais
| WPRIM
| ID: wpr-177686
ABSTRACT
Specialized clinical cell processing began in the Department of Transfusion Medicine at the National Institutes of Health in 1984. The number and complexity of procedures performed increased quickly and in 1997 a highly specialized cell processing laboratory was opened. The laboratory has approximately 3,000 square feet, specialized air handing, a highly trained staff, and written laboratory procedures. In addition to standard laboratory equipment, the laboratory has numerous cell isolation instruments, flow cytometers, and automated cell counting instruments. The laboratory supports blood and bone marrow transplant protocols by isolating CD34+ stem cells, removing T lymphocytes, culturing lymphocytes to eliminate donor lymphocytes that are reactive with recipient alloantigens, and stimulating lymphocytes to induce Th2 type cells to reduce graft versus host disease. The laboratory has also been preparing dendritic cells to support protocols using immune therapy to treat cancer. In addition, pancreatic islet cells are isolated from organ donors for transplantation to treat type I diabetes mellitus.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
États-Unis
/
Cellules souches hématopoïétiques
/
Séparation cellulaire
/
Transplantation d'ilots de Langerhans
/
Transfusion de lymphocytes
/
Transplantation cellulaire
/
Antigènes CD34
/
Immunothérapie
/
Laboratoires
/
Tumeurs
Type d'étude:
Guide de pratique
Limites du sujet:
Humains
Pays comme sujet:
Amérique du Nord
langue:
Anglais
Texte intégral:
Yonsei Medical Journal
Année:
2004
Type:
Article
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