Stevens-Johnson Syndrome Caused by Dapsone / 대한피부과학회지

ABSTRACT

Dapsone (4,4'-diaminodiphenylsulfone) has been widely used in the treatment of leprosy and for a variety of dermatoses. It rarely may result in unpredictable fatal effects such as agranulocytosis, dapsone syndrome, fulminant hepatitis or Stevens-Johnson syndrome (SJS). SJS is a life-threatening, acute hypersensitivity reaction to drugs characterized by atypical targetoid lesions, confluent erythematous purpuric macules and mucocutaneous blisterings. More than 100 medications have been implicated in the pathogenesis of SJS. To the best of our knowledge, there have been only a few reports in the literature of SJS caused by dapsone. Herein we present two cases of SJS that were likely induced by administration of dapsone.