Genetic Signatures of Asthma Exacerbation
Allergy, Asthma & Immunology Research
; : 191-199, 2017.
Article
de En
| WPRIM
| ID: wpr-179289
Bibliothèque responsable:
WPRO
ABSTRACT
Asthma exacerbation (AE) usually denotes worsening of asthma symptoms that requires intense management to prevent further deterioration. AE has been reported to correlate with clinical and demographic factors, such as race, gender, and treatment compliance as well as environmental factors, such as viral infection, smoking, and air pollution. In addition, recent observations suggest that there are likely to be genetic factors specific to AE. Understanding genetic factors specific to AE is essential to develop therapy tailored for exacerbation-prone asthma. Here, we summarize the results of studies involving genetic risk factors for AE. To simplify and enhance understanding, we reviewed the studies according to the following categories: hypothesis-driven approaches, hypothesis-free approaches, gene-environment interactions, and pharmacogenetics.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacogénétique
/
Asthme
/
Fumée
/
Fumer
/
Démographie
/
Facteurs de risque
/
Compliance
/
38409
/
Pollution de l'air
/
Étude d'association pangénomique
Type d'étude:
Etiology_studies
/
Risk_factors_studies
Limites du sujet:
Humans
langue:
En
Texte intégral:
Allergy, Asthma & Immunology Research
Année:
2017
Type:
Article