Alterations of HLA Class I and II Antigen Expressions in Borderline, Invasive and Metastatic Ovarian Cancers / 대한암학회지
Journal of the Korean Cancer Association
;
: 1031-1042, 2000.
Article
Dans Coréen
| WPRIM
| ID: wpr-179729
ABSTRACT
PURPOSE:
The relationship between altered HLA expressions and ovarian carcinogenesis is not fully elucidated. MATERIALS ANDMETHODS:
Histological evaluation comprised 20 serous adenocarcinoma, 5 borderline serous malignancy, 10 mucinous adenocarcinoma, 15 borderline mucinous malignancy. We used monoclonal antibodys to HLA class I beta2-microglobulin, class I B/C and class II heavy chain.RESULTS:
There was no statistical difference in HLA expressions between borderline serous malignancy and normal ovarian tissue. In serous adenocarcinoma, beta2-microglobulin, B/C and class II heavy chain expressions were down-regulated. In metastatic cancer, B/C and class II ex pressions were also down-regulated. But the HLA expression of tumor or normal stromal tissue in primary tumor, were not down-regulated compared with the tissues in metastasis. In borderline mucinous malignancy, class II expressions were down-regulated. In mucinous adenocarcinoma, beta2-microglobulin, B/C and class II expressions were down-regulated. In metastatic ovarian cancer, B/C and class II expressions were down-regulated. But, in borderline malignancy, the result failed to reach statistical significance except class II of borderline mucinous malignancy.CONCLUSION:
Loss of HLA class I and II molecules in invasive ovarian cancers raises the possibility that this could be a mechanism for tumor cells to have invasiveness.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs de l'ovaire
/
Adénocarcinome
/
Adénocarcinome mucineux
/
Carcinogenèse
/
Mucines
/
Métastase tumorale
langue:
Coréen
Texte intégral:
Journal of the Korean Cancer Association
Année:
2000
Type:
Article
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