Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts
Allergy, Asthma & Immunology Research
;
: 288-295, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-17987
ABSTRACT
Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification of their pharmacologic properties predated the cloning of their classical receptors and the development of drugs that modify their synthesis and actions. Recent studies have revealed unanticipated insights into the regulation of cys-LT synthesis, the function of the cys-LTs in innate and adaptive immunity and human disease, and the identification of a new receptor for the cys-LTs. This review highlights these studies and summarizes their potential pathobiologic and therapeutic implications.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Asthme
/
Arachidonate 5-lipoxygenase
/
Leucotriènes
/
Clones cellulaires
/
Acide arachidonique
/
Médiateurs de l'inflammation
/
Clonage d'organisme
/
Immunité acquise
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Allergy, Asthma & Immunology Research
Année:
2014
Type:
Article
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