A Case of Fatal Fenazaquin Intoxication Showing Severe Lactic Acidosis
Journal of the Korean Society of Emergency Medicine
;
: 520-523, 2010.
Article
Dans Coréen
| WPRIM
| ID: wpr-180107
ABSTRACT
Fenazaquin (4-[[4 (1,1-dimethylethyl) pheynyl]ethoxy]quinazoline) is an insecticide that inhibits NADH ubiquinone oxidoreductase of the mitochondria, which is also known as complex I. An 83 year old female was brought to our emergency department (ED) having been found collapsed and unconscious at home by her family. She had ingested up to 100 ml from a bottle of 20% fenazaquin solution. In the ED, she showed severe persistent lactic acidosis despite a seemingly stable hemodynamic condition. Despite intensive supportive management, including positive pressure ventilation, packed red cell transfusion, hemodialysis, and intravenous N-acetylcysteine administration, the lactic acidosis did not respond. To our knowledge, this is the first report of fenazaquin poisoning in humans. No antidote for fenazaquin is known. In this case report, we discuss clinical characteristics and possible pathophysiologic mechanism of fenazaquin poisoning with a literature review.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Acétylcystéine
/
Quinazolines
/
/
Acidose lactique
/
Ventilation à pression positive
/
Dialyse rénale
/
Complexe I de la chaîne respiratoire
/
Urgences
/
Hémodynamique
/
Mitochondries
Limites du sujet:
Femelle
/
Humains
langue:
Coréen
Texte intégral:
Journal of the Korean Society of Emergency Medicine
Année:
2010
Type:
Article
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