Transfusion-related Cytomegalovirus Infection Among Very Low Birth Weight Infants in an Endemic Area
Journal of Korean Medical Science
;
: 5-10, 2006.
Article
Dans Anglais
| WPRIM
| ID: wpr-181127
ABSTRACT
This study investigated the incidence of acquired cytomegalovirus (CMV) infection in very low birth weight infants (VLBWI) given CMV seropositive blood, and sought to determine whether filtering and irradiation of blood products could help prevent CMV infection and the time required to clear passively-derived anti-CMV IgG among 80 VLBWI transfused with filtered-irradiated blood, 20 VLBWI transfused with nonfiltered- nonirradiated blood and 26 nontransfused VLBWI. CMV IgG and IgM values were obtained from all blood products prior to transfusions, and from VLBWI at birth until the infants became seronegative. Urine was obtained for CMV culture at birth and every 3-4 weeks until 12 weeks after the final transfusion. The incidence of CMV IgG seropositivity among the 126 infants at birth and the blood products given were 96% and 95%, respectively. The incidence of acquired CMV infection was 4/100 (4%) in the transfused group 2/80 (2.5%) and 2/20 (10%) in the filtered-irradiated and nonfiltered-nonirradiated transfusion groups, respectively. Approximately 9-10 months elapsed to clear passively acquired CMV IgG. The irradiation and filtering of the blood products did not seem to decrease the transfusion-related CMV infection rate in Korea among VLBWI, however, further validation is recommended in a larger cohort of infants.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Facteurs temps
/
Donneurs de sang
/
Transfusion sanguine
/
Immunoglobuline G
/
Immunoglobuline M
/
Étude comparative
/
Unités de soins intensifs néonatals
/
Modèles linéaires
/
Infections à cytomégalovirus
/
Nourrisson très faible poids naissance
Type d'étude:
Étude pronostique
Limites du sujet:
Femelle
/
Humains
/
Mâle
/
Nouveau-né
langue:
Anglais
Texte intégral:
Journal of Korean Medical Science
Année:
2006
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS