Associations among Body Mass Index, Insulin Resistance, and Pancreatic beta-Cell Function in Korean Patients with New-Onset Type 2 Diabetes
The Korean Journal of Internal Medicine
;
: 66-71, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-181915
ABSTRACT
BACKGROUND/AIMS:
We investigated the associations among body mass index (BMI), insulin resistance, and beta-cell function in Korean patients newly presenting with type 2 diabetes.METHODS:
In total, 132 patients with new-onset type 2 diabetes mellitus were investigated. A standard 75-g oral glucose tolerance test was performed, and the indices of insulin secretion and insulin resistance were calculated.RESULTS:
A higher BMI was associated with higher homeostasis model assessment values for insulin resistance (HOMA-IR), homeostasis model assessment of beta-cell function (HOMA-beta), and insulinogenic index as well as lower levels of insulin sensitivity index composite (ISIcomp) and disposition index (DI). In multiple regression models, BMI had independent positive associations with HOMA-IR, ISIcomp, and HOMA-beta and inverse associations with the DI.CONCLUSIONS:
Our results showed that BMI had independent positive associations with indices of insulin resistance and an inverse association with beta-cell function adjusted for insulin resistance in Korean patients newly presenting with type 2 diabetes.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Glycémie
/
Hémoglobine glyquée
/
Insulinorésistance
/
Marqueurs biologiques
/
Indice de masse corporelle
/
Modèles linéaires
/
Modèles logistiques
/
Analyse multifactorielle
/
Valeur prédictive des tests
/
Facteurs de risque
Type d'étude:
Etude d'étiologie
/
Étude pronostique
Limites du sujet:
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
The Korean Journal of Internal Medicine
Année:
2012
Type:
Article
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