NF-kappaB and CREB Are Involved in IL-8 Production of Human Neutrophils Induced by Trichomonas vaginalis-Derived Secretory Products
The Korean Journal of Parasitology
;
: 291-294, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-182102
ABSTRACT
Trichomonas vaginalis is a flagellated lumen-dwelling extracellular protozoan parasite that causes human trichomoniasis via sexual intercourse. Human neutrophils play a crucial role in acute tissue inflammatory responses in T. vaginalis infection. In this study, we investigated the signaling mechanism of neutrophil responses when stimulated with T. vaginalis-derived secretory products (TvSP), which were collected from 1x10(7) live trichomonads. Incubation of human neutrophils isolated from peripheral blood with TvSP induced up-regulation of IL-8 protein secretion. In addition, stimulation with TvSP induced phosphorylation of NF-kappaB and CREB in neutrophils. Moreover, TvSP-induced IL-8 production was also significantly inhibited by pretreatment of neutrophils with ikappaB inhibitor or CREB inhibitor. These results suggest that transcription factors NF-kappaB and CREB are involved in IL-8 production in human neutrophils induced by stimulation with T. vaginalis infection.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phosphorylation
/
Trichomonas vaginalis
/
Interleukine-8
/
Facteur de transcription NF-kappa B
/
Protéine de liaison à l'élément de réponse à l'AMP cyclique
/
Expérimentation humaine
/
Granulocytes neutrophiles
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
The Korean Journal of Parasitology
Année:
2011
Type:
Article
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