Short term outcomes of topiramate monotherapy as a first-line treatment in newly diagnosed West syndrome / 소아과
Korean Journal of Pediatrics
;
: 380-384, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-182117
ABSTRACT
PURPOSE:
To investigate the efficacy of topiramate monotherapy in West syndrome prospectively.METHODS:
The study population included 28 patients (15 male and 13 female children aged 2 to 18 months) diagnosed with West syndrome. After a 2-week baseline period for documentation of the frequency of spasms, topiramate was initiated at 2 mg/kg/day. The dose was increased by 2 mg/kg every week to a maximum of 12 mg/kg/day. Clinical assessment was based on the parents' report and a neurological examination every 2 weeks for the first 2 months of treatment. The baseline electroencephalograms (EEGs) were compared with the post-treatment EEGs at 2 weeks and 1 month.RESULTS:
West syndrome was considered to be cryptogenic in 7 of the 28 patients and symptomatic in 21 patients. After treatment, 11 patients (39%) became spasm-free, 6 (21%) had more than 50% spasmsreduction, 3 (11%) showed less than 50% reduction, and 8 (29%) did not respond. The effective daily dose for achieving more than 50% reduction in spasm frequency, including becoming spasm-free, was found to be 5.8+/-1.1 mg/kg/day. Nine patients (32%) showed complete disappearance of spasms and hypsarrhythmia, and 11 (39%) showed improved EEG results. Despite adverse events (4 instances of irritability, 3 of drowsiness, and 1 of decreased feeding), no patients discontinued the medication.CONCLUSION:
Topiramate monotherapy seems to be effective and well tolerated as a first line therapy for West syndrome and is not associated with serious adverse effects.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phases du sommeil
/
Spasme
/
Spasmes infantiles
/
Électroencéphalographie
/
Fructose
/
Examen neurologique
Type d'étude:
Etude diagnostique
Limites du sujet:
Adulte très âgé
/
Enfant
/
Femelle
/
Humains
/
Bébé
/
Mâle
/
Nouveau-né
langue:
Anglais
Texte intégral:
Korean Journal of Pediatrics
Année:
2011
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS