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Identification of Dammarane-type Triterpenoid Saponins from the Root of Panax ginseng
Natural Product Sciences ; : 111-121, 2015.
Article Dans Anglais | WPRIM | ID: wpr-182832
ABSTRACT
The root of Panax ginseng, is a Korea traditional medicine, which is used in both raw and processed forms due to their different pharmacological activities. As part of a continued chemical investigation of ginseng, the focus of this research is on the isolation and identification of compounds from Panax ginseng root by open column chromatography, medium pressure liquid chromatography, semi-preparative-high performance liquid chromatography, Fast atom bombardment mass spectrometric, and nuclear magnetic resonance. Dammarane-type triterpenoid saponins were isolated from Panax ginseng root by open column chromatography, medium pressure liquid chromatography, and semi-preparative-high performance liquid chromatography. Their structures were identified as protopanaxadiol ginsenosides [gypenoside-V (1), ginsenosides-Rb1 (2), -Rb2 (3), -Rb3 (4), -Rc (5), and -Rd (6)], protopanaxatriol ginsenosides [20(S)-notoginsenoside-R2 (7), notoginsenoside-Rt (8), 20(S)-O-glucoginsenoside-Rf (9), 6-O-[alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl]-20-O-beta-D-glucopyranosyl-3beta,12beta, 20(S)-dihydroxy-dammar-25-en-24-one (10), majoroside-F6 (11), pseudoginsenoside-Rt3 (12), ginsenosides-Re (13), -Re5 (14), -Rf (15), -Rg1 (16), -Rg2 (17), and -Rh1 (18), and vinaginsenoside-R15 (19)], and oleanene ginsenosides [calenduloside-B (20) and ginsenoside-Ro (21)] through the interpretation of spectroscopic analysis. The configuration of the sugar linkages in each saponin was established on the basic of chemical and spectroscopic data. Among them, compounds 1, 8, 10, 11, 12, 19, and 20 were isolated for the first time from P. ginseng root.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Saponines / Spectroscopie par résonance magnétique / Chromatographie / Chromatographie en phase liquide / Ginsénosides / Médecine traditionnelle coréenne / Panax Type d'étude: Etude diagnostique langue: Anglais Texte intégral: Natural Product Sciences Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Saponines / Spectroscopie par résonance magnétique / Chromatographie / Chromatographie en phase liquide / Ginsénosides / Médecine traditionnelle coréenne / Panax Type d'étude: Etude diagnostique langue: Anglais Texte intégral: Natural Product Sciences Année: 2015 Type: Article