Risk Factors for Post-ERCP Pancreatitis in Patients Pretreated with Nafamostat Mesilate / 대한소화기내시경학회지
Korean Journal of Gastrointestinal Endoscopy
; : 265-270, 2008.
Article
de Ko
| WPRIM
| ID: wpr-183193
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGOUND/AIMS: Pancreatitis is the most common and important complication of an endoscopic retrograde cholangiopancreatography (ERCP). The aim of this study was to identify risk factors for post ERCP-pancreatitis in patients pretreated with nafamostat mesilate, a synthetic protease inhibitor. METHODS: A total of 247 patients who underwent an ERCP were evaluated prospectively. Potential risk factors of post-ERCP pancreatitis in patients pretreated with nafamostat mesilate were evaluated. RESULTS: Twenty-four patients (9.7%) and nine patients (3.6%) developed post-ERCP hyperamylasemia and pancreatitis, respectively. As determined by univariate analysis among the potential risk factors, we found a procedure time over 20 minutes, pancreatic duct cannulation over four times, prior post-ERCP pancreatitis and the absence of a common bile duct (CBD) stone as risk factors for post-ERCP hyperamylasemia. We also found a patient age under 60 years, a procedure time over 20 minutes, pancreatic duct cannulation over four times and the absence of a CBD stone as risk factors for post-ERCP pancreatitis (p<0.05). As determined by multivariate analysis, pancreatic cannulation over four times is independently associated with post-ERCP hyperamylasemia (p=0.038; OR, 5.165; 95% CI, 1.093~24.412) and post-ERCP pancreatitis (p=0.002; OR, 33.122; 95% CI, 3.526~311.138). CONCLUSIONS: A repeated pancreatic duct cannulation is the most important risk factor for post-ERCP pancreatitis in patients pretreated with nafamostat mesilate.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Conduits pancréatiques
/
Pancréatite
/
Inhibiteurs de protéases
/
Cathétérisme
/
Analyse multifactorielle
/
Études prospectives
/
Facteurs de risque
/
Cholangiopancréatographie rétrograde endoscopique
/
Conduit cholédoque
/
Méthanesulfonates
Type d'étude:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Korean Journal of Gastrointestinal Endoscopy
Année:
2008
Type:
Article