Completion of Chronic Hepatitis C Virus Treatment in Interferon-Induced Major Depressive Disorder with Psychotic Features
Psychiatry Investigation
;
: 381-383, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-183453
ABSTRACT
Interferon (IFN)-associated psychiatric disorders can be managed without interruption to hepatitis C virus (HCV) treatment. The limited number of cases in the literature reporting psychotic depression as an adverse drug reaction to IFN resulted in discontinuation of HCV therapy. The author reports a case of a 49 year-old man with chronic HCV genotype 1a treated with pegylated interferon-alpha and ribavirin developing major depressive disorder with psychotic features. The patient was successfully treated with both an antidepressant and antipsychotic for this suspected IFN-associated adverse drug effect while continuing 12 months of uninterrupted HCV treatment and subsequently achieving sustained hepatitis C virological response. Although IFN can cause distressing psychiatric disturbances, appropriate treatment with psychotropic agents and careful monitoring allows patients to be maintained on a full course of HCV treatment.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Troubles psychotiques
/
Ribavirine
/
Interférons
/
Interféron alpha
/
Hépatite C
/
Hepacivirus
/
Hépatite C chronique
/
Dépression
/
Trouble dépressif majeur
/
Effets secondaires indésirables des médicaments
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Psychiatry Investigation
Année:
2011
Type:
Article
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