A clinical study of congenital chylothorax and octreotide therapy / 소아과
Korean Journal of Pediatrics
;
: 1172-1178, 2008.
Article
Dans Coréen
| WPRIM
| ID: wpr-18369
ABSTRACT
PURPOSE:
Congenital chylothorax is an accumulation of lymphatic fluid within the pleural space. It is a common cause of unidentified hydrops fetalis. We examined the perinatal history, clinical manifestation, diagnosis, treatment, and outcome in 6 newborns diagnosed to have congenital chylothorax with hydrops fetalis. We also studied the effect of octreotide therapy for congenital chylothorax in relation to conservative treatment.METHODS:
We retrospectively reviewed the medical records of 6 patients diagnosed to have congenital chylothorax with hydrops fetalis among 27,907 newborns who were born at the Cheil General Hospital and Womens Healthcare Center between January 2004 and July 2007 . The diagnosis of chylothorax is based on the analysis of pleural fluid before and after milk feeding.RESULTS:
Incidence of congenital chylothorax in this study was 0.021%. All 6 cases were noted in over the 92% lymphocyte in pleural analysis. Transudate was changed into chyle with increasing triglyceride levels above 200 mg/dL after milk feeding. Three of 6 infants improved with conservative treatment, including thoracostomy and assisted ventilation. The others had persistent symptoms despite conservative treatment and responded to octreotide therapy. A complication, specifically vomiting was noted in 1 case during octreotide therapy.CONCLUSION:
In this study, octreotide therapy resulted in a safe and excellent outcome. Therefore, octreotide therapy is considered in severe refractory congenital chylothorax in conservative treatment. Further studies are required to determine appropriate guidelines for octreotide therapy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ventilation
/
Vomissement
/
Thoracostomie
/
Lymphocytes
/
Anasarque foetoplacentaire
/
Octréotide
/
Dossiers médicaux
/
Incidence
/
Études rétrospectives
/
Chyle
Type d'étude:
Guide de pratique
/
Etude d'incidence
/
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Femelle
/
Humains
/
Bébé
/
Nouveau-né
langue:
Coréen
Texte intégral:
Korean Journal of Pediatrics
Année:
2008
Type:
Article
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