Cisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment Strategies
Electrolytes & Blood Pressure
; : 55-65, 2014.
Article
de En
| WPRIM
| ID: wpr-183770
Bibliothèque responsable:
WPRO
ABSTRACT
Cisplatin is one of the most widely used and highly effective drug for the treatment of various solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and nerves. Nephrotoxicity is the most well-known and clinically important toxicity. Numerous studies have demonstrated that several mechanisms, including oxidative stress, DNA damage, and inflammatory responses, are closely associated with cisplatin-induced nephrotoxicity. Even though the establishment of cisplatin-induced nephrotoxicity can be alleviated by diuretics and pre-hydration of patients, the prevalence of cisplatin nephrotoxicity is still high, occurring in approximately one-third of patients who have undergone cisplatin therapy. Therefore it is imperative to develop treatments that will ameliorate cisplatin-nephrotoxicity. In this review, we discuss the mechanisms of cisplatin-induced renal toxicity and the new strategies for protecting the kidneys from the toxic effects without lowering the tumoricidal activity.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Altération de l'ADN
/
Prévalence
/
Cisplatine
/
Stress oxydatif
/
Diurétiques
/
Traitement médicamenteux
/
Rein
Type d'étude:
Prevalence_studies
Limites du sujet:
Humans
langue:
En
Texte intégral:
Electrolytes & Blood Pressure
Année:
2014
Type:
Article