Economic Impact of Combining Metformin with Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients with Renal Impairment in Spanish Patients
Diabetes & Metabolism Journal
;
: 74-81, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-185090
ABSTRACT
BACKGROUND:
To evaluate resource use and health costs due to the combination of metformin and dipeptidyl peptidase-4 (DPP-4) inhibitors in patients with diabetes and renal impairment in routine clinical practice.METHODS:
An observational, retrospective study was performed. Patients aged > or =30 years treated with metformin who initiated a second oral antidiabetic treatment in 2009 to 2010 were included. Two groups of patients were analysed metformin+DPP-4 inhibitors and other oral antidiabetics. The main measures were compliance, persistence, metabolic control (glycosylated hemoglobin< 7%) and complications (hypoglycemia, cardiovascular events) and total costs. Patients were followed up for 2 years.RESULTS:
We included 395 patients, mean age 70.2 years, 56.5% male 135 patients received metformin+DPP-4 inhibitors and 260 patients received metformin+other oral antidiabetics. Patients receiving DPP-4 inhibitors showed better compliance (66.0% vs. 60.1%), persistence (57.6% vs. 50.0%), and metabolic control (63.9% vs. 57.3%), respectively, compared with those receiving other oral antidiabetics (P<0.05), and also had a lower rate of hypoglycemia (20.0% vs. 47.7%) and lower total costs (euro 2,486 vs. euro 3,002), P=0.001.CONCLUSION:
Despite the limitations of the study, patients with renal impairment treated with DPP-4 inhibitors had better metabolic control, lower rates (association) of hypoglycaemia, and lower health costs for the Spanish national health system.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Études rétrospectives
/
Coûts des soins de santé
/
Compliance
/
Inhibiteurs de la dipeptidyl-peptidase IV
/
Hypoglycémie
/
Hypoglycémiants
/
Metformine
Type d'étude:
Évaluation en économique de la santé
/
Étude observationnelle
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Diabetes & Metabolism Journal
Année:
2015
Type:
Article
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