Clinical Efficacy and Safety of Naltrexone Combination Therapy in Older Patients with Severe Pruritus
Annals of Dermatology
;
: 159-163, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-185203
ABSTRACT
BACKGROUND:
Severe pruritus is a challenging condition, and it is more difficult to deal with in older patients due to their limitations in taking oral medication because of underlying diseases, possible interaction with concurrent medications, and poor general condition.OBJECTIVE:
We evaluated the efficacy and safety of naltrexone (Revia®), an opioid antagonist, in elderly patients with severe pruritus that was not easily controlled with conventional antipruritics.METHODS:
Eighteen patients were enrolled, with a mean age of 73 years. They additionally received 50 mg of naltrexone per day for an average of 2 months.RESULTS:
Using the visual analogue scale, 13 (72.2%) of 18 patients showed a "much improved" condition, reporting more than a 50% decrease in pruritus intensity. Sixteen (88.9%) showed symptomatic improvement, and only 2 (11.1%) had persistent pruritus. Five patients reported side effects including insomnia, fatigue, constipation, and anorexia. However, reactions were either limited to the first 2 weeks or well managed.CONCLUSION:
Naltrexone could be an effective and safe alternative treatment option to control severe pruritus in older patients.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Prurit
/
Anorexie
/
Constipation
/
Fatigue
/
Troubles de l'endormissement et du maintien du sommeil
/
Naltrexone
/
Antiprurigineux
Limites du sujet:
Adulte très âgé
/
Humains
langue:
Anglais
Texte intégral:
Annals of Dermatology
Année:
2016
Type:
Article
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