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A Case of Levofloxacin-Induced Anaphylaxis With Elevated Serum Tryptase Levels
Allergy, Asthma & Immunology Research ; : 113-115, 2013.
Article Dans Anglais | WPRIM | ID: wpr-186060
ABSTRACT
Levofloxacin, a fluoroquinolone and L-isomer of the racemate ofloxacin, has been approved for the treatment of acute and chronic bacterial infections. Gastrointestinal complaints are the most frequently reported adverse drug reactions to fluoroquinolones. Other adverse events include headache, dizziness, increased liver enzyme levels, photosensitivity, tachycardia, QT prolongation, and eruptions. Anaphylaxis has been documented as a rare adverse drug reaction to levofloxacin; however, diagnostic tests are needed to evaluate whether these reactions are the result of levofloxacin treatment. While the results of skin tests are considered unreliable due to false-positive responses, the oral provocation test is currently considered to be the most reliable test. Tryptase, a neutral protease, is the dominant protein component of secretory granules in human mast cells, and an increased serum concentration of tryptase is a highly sensitive indicator of anaphylaxis. Herein, we report a case of levofloxacin-induced anaphylaxis in which the patient exhibited elevated serum tryptase levels and a positive oral levofloxacin challenge test result. As anaphylaxis is potentially life-threatening, the administration of fluoroquinolones to patients who have experienced a prior reaction to this type of agent should be avoided.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Tachycardie / Infections bactériennes / Tests cutanés / Ofloxacine / Vésicules de sécrétion / Fluoroquinolones / Tests diagnostiques courants / Sensation vertigineuse / Hypersensibilité médicamenteuse / Effets secondaires indésirables des médicaments Limites du sujet: Humains langue: Anglais Texte intégral: Allergy, Asthma & Immunology Research Année: 2013 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Tachycardie / Infections bactériennes / Tests cutanés / Ofloxacine / Vésicules de sécrétion / Fluoroquinolones / Tests diagnostiques courants / Sensation vertigineuse / Hypersensibilité médicamenteuse / Effets secondaires indésirables des médicaments Limites du sujet: Humains langue: Anglais Texte intégral: Allergy, Asthma & Immunology Research Année: 2013 Type: Article