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Involvement of Protein Kinase C-delta in Vascular Permeability in Acute Lung Injury
Immune Network ; : 206-211, 2015.
Article Dans Anglais | WPRIM | ID: wpr-186449
ABSTRACT
Pulmonary edema is a major cause of mortality due to acute lung injury (ALI). The involvement of protein kinase C-delta (PKC-delta) in ALI has been a controversial topic. Here we investigated PKC-delta function in ALI using PKC-delta knockout (KO) mice and PKC inhibitors. Our results indicated that although the ability to produce proinflammatory mediators in response to LPS injury in PKC-delta KO mice was similar to that of control mice, they showed enhanced recruitment of neutrophils to the lung and more severe pulmonary edema. PKC-delta inhibition promoted barrier dysfunction in an endothelial cell layer in vitro, and administration of a PKC-delta-specific inhibitor significantly increased steady state vascular permeability. A neutrophil transmigration assay indicated that the PKC-delta inhibition increased neutrophil transmigration through an endothelial monolayer. This suggests that PKC-delta inhibition induces structural changes in endothelial cells, allowing extravasation of proteins and neutrophils.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Protein kinases / Oedème pulmonaire / Perméabilité capillaire / Mortalité / Cellules endothéliales / Protein kinase C-delta / Lésion pulmonaire aigüe / Poumon / Granulocytes neutrophiles Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Immune Network Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Protein kinases / Oedème pulmonaire / Perméabilité capillaire / Mortalité / Cellules endothéliales / Protein kinase C-delta / Lésion pulmonaire aigüe / Poumon / Granulocytes neutrophiles Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Immune Network Année: 2015 Type: Article