The experimental study of the bone regeneration on beta-TCP in rabbit cranial bone
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 282-291, 2004.
Article
Dans Coréen
| WPRIM
| ID: wpr-186708
ABSTRACT
Pure-phase beta-tricalcium phosphate(beta-TCP) proved to be a bone regeneration material, providing the patient with vital bone at the defect site in a reasonable time, making a second surgical procedure for bone harvesting unnecessary. This study compares bone healing and BMP 2/4 expression in cranial defects in rabbits grafted with autogenous bone and beta-TCP. Thirty New Zealand White rabbits was divided into 3 group of 10 animals each. Bilateral calvarial defects were made in the parietal bones of each animal. beta-TCP placed in one defect and the other defects was filled with autogenous bone. The animal were sacrificed at 4, 8 and 12 weeks. Immunohistochemical analysis was used to investigate the expression of BMP 2/4. 1. The new bone formation around autogenous bone from 4 weeks and beta-TCP from 8 weeks. 2. In autogenous bone graft, BMP 2/4 expression was decreased from 4 to 12 weeks. 3. In beta-TCP graft, BMP 4 expression was increased from 8 to 12 weeks. But, BMP 2 was observed from 12 weeks. This study showed that bone healing, regeneration and, BMP 2/4 expression are delayed in grafted beta-TCP than autogenous bone.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ostéogenèse
/
Os pariétal
/
Régénération
/
Régénération osseuse
/
Transplants
Limites du sujet:
Animaux
/
Humains
langue:
Coréen
Texte intégral:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Année:
2004
Type:
Article
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