Histologic Changes of the Hippocampal Neural Pathway in the Alzheimer's Disease

ABSTRACT

In this study the quantitative changes of the SP (senile plaque) and NFT (neurofibrillary tangle) in the intrinsic hippocampal neural circuit were analyzed. All patients (86 case) were diagnosed clinically and confirmed pathologically as Alzheimer disease. The results were 1) The NET and SP were most prominenetly observed in the C/A1 region, but they were not so many in the CA2 and CA3 regions. 2) There were quantitative correlation between the NFT and the SP except in the presubiculum and the dentate fascia. 3) There were no significant rank correlation between the perikaryonic NFT and the terminal SP in the dentate fascia and the CA3 area. 4) There were significant statistic difference of the quantity of the NFT and the SP between each neighboring areas in the intrinsic hippocampal neural circuit. I think there could be some influences of cholinergic fiber that they were from the medial septal nuclei and the nuclei of the diagonal band to the dentate fascia and the CA3 area.