A Case of Resistance to Thyroid Hormone with Thyroid Cancer
Journal of Korean Medical Science
;
: 1368-1371, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-187903
ABSTRACT
Resistance to thyroid hormone (RTH) is an autosomal dominant hereditary disorder that is difficult to diagnose because of its rarity and variable clinical features. The magnitude of RTH is caused by mutations in the thyroid hormone receptor beta (TRbeta) gene. We recently treated a 38-yr-old woman with RTH who had incidental papillary thyroid carcinoma. She presented with goiter and displayed elevated thyroid hormone levels with an unsuppressed TSH. She was determined to harbor a missense mutation of M310T in exon 9 of the TRbeta gene, and diagnosed with generalized RTH. This mutation has not yet been reported in Korea. RTH is very rare and easily overlooked, but should be considered in patients who present with goiter and elevated thyroid hormone levels with an unsuppressed TSH. The association between thyroid cancer and RTH needs further study.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Glande thyroide
/
Hormones thyroïdiennes
/
Tumeurs de la thyroïde
/
Exons
/
Syndrome de résistance aux hormones thyroïdiennes
/
Mutation faux-sens
/
Récepteurs bêta des hormones thyroïdiennes
/
Diagnostic différentiel
Type d'étude:
Etude diagnostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Journal of Korean Medical Science
Année:
2010
Type:
Article
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