The Suppressive Effect of Evening Primrose Oil on Murine Contact Sensitivity
Annals of Dermatology
;
: 39-44, 1995.
Article
Dans Anglais
| WPRIM
| ID: wpr-18833
ABSTRACT
BACKGROUND:
Evening primrose oil(EPO) is a rich source of cis-linoleic acid and gammalinolenic acid(GLA) and has been used as a therapeutic agent in various skin diseases such as atopic dermatitis.OBJECTIVE:
The purpose of this study was to evaluate the suppressive effect of EPO on murine contact sensitivity.METHODS:
BALB/c mice were divided into 3 groups, positive control, experimental and negative control groups the positive control group represents a group of mice which were sensitized and challenged with DNFB, the experimental group represents EPO-pretreated positive control group and the negative control group represents a group of mice which were challenged only. The changes of ear thickness were measured, and H & E staining and immunohistochemical staining for ICAM-1 expression of ear skin were performed to evaluate the histological changes of each group.RESULTS:
The Pretreatment of mice with EPO resulted in suppression of contact sensitivity by more than 82%. On H & E staining, only a mild inflammatory reaction was observed in the dermis. Also ICAM-1 expression of keratinocytes, the intensity of the staining was significantly decreased in the experimental group compared with positive group.CONCLUSIONS:
Our study indicates that EPO was able to suppress the induction of contact sensitivity.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Peau
/
Maladies de la peau
/
Kératinocytes
/
Oenothera biennis
/
Molécule-1 d'adhérence intercellulaire
/
Derme
/
Eczéma atopique
/
Eczéma de contact
/
1-Fluoro-2,4-dinitro-benzène
/
Oreille
Type d'étude:
Etude diagnostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Annals of Dermatology
Année:
1995
Type:
Article
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