A Case of Pulmonary Thromboembolism with JAK2 Mutation / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 351-355, 2009.
Article
Dans Coréen
| WPRIM
| ID: wpr-190768
ABSTRACT
The incidence of pulmonary thromboembolism increases with age. The risk factors of pulmonary thromboembolism include surgery, malignancy, obesity, lupus anticoagulants, and vascular conditions such as deep vein thrombosis. Thromboembolism in younger patients or in unusual locations, the possibility of primary thrombophilic conditions should be considered. Primary thrombophilic states include myeloproliferative disorders (MPD). JAK2 V617F mutation is found commonly in patients diagnosed with MPD, in 90~95% of polycythemia vera (PV) and in 50~60% of essential thrombocytosis (ET) patients. Sometimes the JAK2 V617F mutation is found in cases without MPD. The relationship between JAK2 V617F mutation and thrombosis has not been defined. Recently, clinical evidence suggests that this mutation may be variably associated with thrombosis. We present one case of pulmonary thromboembolism in a young patient, who was positive for the JAK2 V617F mutation and did not have MPD.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polyglobulie primitive essentielle
/
Embolie pulmonaire
/
Thrombocytose
/
Thromboembolie
/
Thrombose
/
Incidence
/
Facteurs de risque
/
Thrombose veineuse
/
Anticoagulants
/
Syndromes myéloprolifératifs
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Tuberculosis and Respiratory Diseases
Année:
2009
Type:
Article
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