Polymorphism of CTLA4 Gene in Schizophrenia / 신경정신의학

ABSTRACT

OBJECT This study was performed to examine the relationship between immunogenetics and schizophrenia by analyzing polymorphism of CTLA4 gene, which is known to affect the apoptosis and the activation of T cells. METHOD: 116 schizophrenic patients who were diagnosed by DSM-IV and 149 normal controls obtained from the Catholic Hemopoietic Stem Cell Information Bank of Korea were analyzed. After extracting DNA from whole blood, we amplified CTLA4 exon1 genes by polymerase chain reaction and assessed by SSCP. RESULTS: Genotype frequencies of CTLA4 G/G, CTLA4 A/A, and CTLA G/A between patients with schizophrenia and controls were different with statistical significance. Data also showed significant differences in frequencies of CTLA4 A and CTLA4 G alleles between the two groups. CONCLUSION: In this study, we found a partial relataionship between CTLA4 exon 1 +49 region polymophism and schizophrenia. Further systemic studies for larger subjects including adjacent genes and diverse clinical variables in the future may reveal the effects of CTLA4 gene on the susceptibility of schizophrenia.