Effect of Trusopt and Xalatan on the Proliferation of Cultured Subconjunctival Fibro blasts
Journal of the Korean Ophthalmological Society
;
: 1642-1648, 1999.
Article
Dans Coréen
| WPRIM
| ID: wpr-192785
ABSTRACT
The prior long-term use of topical anti-glaucoma medications has been suggested as an adverse factor for the outcome of trabeculectomy. The mechanism of action is still unclear. This study investigates the effect of Trusopt and Xalatan on the proliferation and viability of human Tenon`s capsule fibroblasts in tissue culture. We examined the effect of two commercial drugs, Trusopt and Xalatan, and pure benzalkonium chloride, at various dilution, on the proliferation as assessed by MTT assay and assessed micro-scopically the viability of human Tenon's capsule fibroblasts in tissue culture. None of the tested compounds stimulated proliferation of fibroblasts in tissue culture and inhibited proliferation. All had toxic effects on cell morphology. These results show an antiproliferative and toxic effect of Trusopt and Xalatan on the fibroblasts in tissue culture and no direct stimulation of fibroblast proliferation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Composés de benzalkonium
/
Trabéculectomie
/
Capsule de Tenon
/
Fibroblastes
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Journal of the Korean Ophthalmological Society
Année:
1999
Type:
Article
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