Efficacy of Initial Treatment with Clevudine in Naive Patients with Chronic Hepatitis B
The Korean Journal of Internal Medicine
; : 372-376, 2010.
Article
de En
| WPRIM
| ID: wpr-192816
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS: Clevudine, a pyrimidine nucleoside analogue, has potent antiviral effects in patients with chronic viral hepatitis B (CHB). We report the efficacy of initial treatment with clevudine in naive patients with CHB living in Daejeon and Chungcheong Province, South Korea. METHODS: One hundred five adults with CHB were administered 30 mg of clevudine per day for an average of 51 weeks. We evaluated viral markers and liver biochemistry retrospectively every 3 months. RESULTS: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatitis B virus (HBV) DNA before the treatment were 184 +/- 188 IU/L, 150 +/- 138 IU/L, and 7.1 +/- 1.2 log copies/mL, respectively. Undetectable rates (< 60 IU/mL) of DNA were 36.2%, 68.9%, 83.6%, 76.2%, and 75.8% at 12, 24, 36, 48, and 60 weeks, respectively. Seroconversion rates were 9.1%, 13.6%, 24.6%, 26.5%, and 26.1% and ALT normalization rates were 64.5%, 78.1%, 87.9%, 90.0% at 12, 24, 36, and 48 weeks, respectively. Six patients (5.7%) had a viral breakthrough. CONCLUSIONS: Clevudine is a useful drug in the initial treatment of patients with CHB, with a potent antiviral effect and low incidence of viral breakthrough.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Antiviraux
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Arabinofuranosyluracile
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Études rétrospectives
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Hépatite B chronique
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Alanine transaminase
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Antigènes e du virus de l'hépatite virale B
Type d'étude:
Observational_studies
Limites du sujet:
Adult
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Female
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Humans
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Male
langue:
En
Texte intégral:
The Korean Journal of Internal Medicine
Année:
2010
Type:
Article